Low Plasma Cefepime Levels in Critically Ill Septic Patients: Pharmacokinetic Modeling Indicates Improved Troughs with Revised Dosing
The pharmacokinetics of a 2-g bolus of cefepime were measured in critically ill patients with normal renal function. Variable and low trough plasma drug concentrations were found, and 8 of 10 patients had levels below the MIC at which 50% of the isolates are inhibited for Pseudomonas aeruginosa. Com...
Shranjeno v:
| izdano v: | Antimicrob Agents Chemother |
|---|---|
| Principais autores: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology (ASM)
1999
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89521/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10508045/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.10.2559 |
| Oznake: |
Brez oznak, prvi označite!
|