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Low Plasma Cefepime Levels in Critically Ill Septic Patients: Pharmacokinetic Modeling Indicates Improved Troughs with Revised Dosing

The pharmacokinetics of a 2-g bolus of cefepime were measured in critically ill patients with normal renal function. Variable and low trough plasma drug concentrations were found, and 8 of 10 patients had levels below the MIC at which 50% of the isolates are inhibited for Pseudomonas aeruginosa. Com...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Antimicrob Agents Chemother
Principais autores: Lipman, J., Wallis, S. C., Rickard, C.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 1999
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89521/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10508045/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.10.2559
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