Low Plasma Cefepime Levels in Critically Ill Septic Patients: Pharmacokinetic Modeling Indicates Improved Troughs with Revised Dosing

The pharmacokinetics of a 2-g bolus of cefepime were measured in critically ill patients with normal renal function. Variable and low trough plasma drug concentrations were found, and 8 of 10 patients had levels below the MIC at which 50% of the isolates are inhibited for Pseudomonas aeruginosa. Com...

Volledige beschrijving

Bibliografische gegevens

Gepubliceerd in:	Antimicrob Agents Chemother
Hoofdauteurs:	Lipman, J., Wallis, S. C., Rickard, C.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 1999
Onderwerpen:	Pharmacology
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89521/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10508045/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.10.2559
Tags:	Voeg label toe Geen labels, Wees de eerste die dit record labelt!