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Low Plasma Cefepime Levels in Critically Ill Septic Patients: Pharmacokinetic Modeling Indicates Improved Troughs with Revised Dosing

The pharmacokinetics of a 2-g bolus of cefepime were measured in critically ill patients with normal renal function. Variable and low trough plasma drug concentrations were found, and 8 of 10 patients had levels below the MIC at which 50% of the isolates are inhibited for Pseudomonas aeruginosa. Com...

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-д хадгалсан:
Номзүйн дэлгэрэнгүй
-д хэвлэсэн:Antimicrob Agents Chemother
Үндсэн зохиолчид: Lipman, J., Wallis, S. C., Rickard, C.
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: American Society for Microbiology (ASM) 1999
Нөхцлүүд:
Онлайн хандалт:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89521/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10508045/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.10.2559
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