Characterization of New Mutations in Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and Identification of Conserved Regions Important for the Catalytic Activity of the Pyrazinamidase PncA

A new set of mutations, including transposition of the insertion sequence IS6110, was identified in the pncA gene from 19 pyrazinamide-resistant Mycobacterium tuberculosis strains. Alignment of the PncA protein from M. tuberculosis with homologous proteins from different bacterial species revealed t...

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Bibliographic Details
Main Authors: Lemaitre, Nadine, Sougakoff, Wladimir, Truffot-Pernot, Chantal, Jarlier, Vincent
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC89359/
https://ncbi.nlm.nih.gov/pubmed/10390238
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