Characterization of New Mutations in Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and Identification of Conserved Regions Important for the Catalytic Activity of the Pyrazinamidase PncA

A new set of mutations, including transposition of the insertion sequence IS6110, was identified in the pncA gene from 19 pyrazinamide-resistant Mycobacterium tuberculosis strains. Alignment of the PncA protein from M. tuberculosis with homologous proteins from different bacterial species revealed t...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Lemaitre, Nadine, Sougakoff, Wladimir, Truffot-Pernot, Chantal, Jarlier, Vincent
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89359/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10390238/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.7.1761
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