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Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia

Abstract Background The ongoing epidemic of multidrug-resistant tuberculosis (MDR-TB) in Georgia highlights the need for more effective control strategies. A new regimen to treat MDR-TB that includes pyrazinamide (PZA) is currently being evaluated and PZA resistance status will largely influence the...

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Principais autores: Sarah Sengstake, Indra L Bergval, Anja R Schuitema, Jessica L de Beer, Jody Phelan, Rina de Zwaan, Taane G Clark, Dick van Soolingen, Richard M Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2017-07-01
coleção:BMC Infectious Diseases
Assuntos:
Mycobacterium tuberculosis
Pyrazinamide
Transmission
Drug resistance
pncA
Acesso em linha:http://link.springer.com/article/10.1186/s12879-017-2594-3
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