Characterization of New Mutations in Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and Identification of Conserved Regions Important for the Catalytic Activity of the Pyrazinamidase PncA

A new set of mutations, including transposition of the insertion sequence IS6110, was identified in the pncA gene from 19 pyrazinamide-resistant Mycobacterium tuberculosis strains. Alignment of the PncA protein from M. tuberculosis with homologous proteins from different bacterial species revealed t...

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書誌詳細

出版年:	Antimicrob Agents Chemother
主要な著者:	Lemaitre, Nadine, Sougakoff, Wladimir, Truffot-Pernot, Chantal, Jarlier, Vincent
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Microbiology (ASM) 1999
主題:	Mechanisms of Resistance
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89359/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10390238/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.7.1761
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