Purification, Reconstitution, and Inhibition of Cytochrome P-450 Sterol Δ(22)-Desaturase from the Pathogenic Fungus Candida glabrata

Sterol Δ(22)-desaturase has been purified from a strain of Candida glabrata with a disruption in the gene encoding sterol 14α-demethylase (cytochrome P-45051; CYP51). The purified cytochrome P-450 exhibited sterol Δ(22)-desaturase activity in a reconstituted system with NADPH–cytochrome P-450 reduct...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Lamb, David C., Maspahy, Segula, Kelly, Diane E., Manning, Nigel J., Geber, Antonia, Bennett, John E., Kelly, Steven L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Mechanisms of Action: Physiological Effects
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89351/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10390230/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.7.1725
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