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Activities of Sordarins in Murine Histoplasmosis

Sordarins are new antifungals which inhibit fungal protein synthesis by blocking elongation factor 2. Three compounds were evaluated in a murine model of histoplasmosis. Immune-competent mice were infected intravenously with 10(6) to 10(8) CFU of Histoplasma capsulatum yeast cells. Mice were treated...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Graybill, John R., Najvar, Laura, Fothergill, Annette, Bocanegra, Rosie, de las Heras, Federico Gomez
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 1999
Soggetti:
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89349/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10390228/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.7.1716
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