In Vivo and In Vitro Toxicodynamic Analyses of New Quinolone-and Nonsteroidal Anti-Inflammatory Drug-Induced Effects on the Central Nervous System

We investigated the correlation between an in vivo isobologram based on the concentrations of new quinolones (NQs) in brain tissue and the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) for the occurrence of convulsions in mice and an in vitro isobologram based on the concentrations...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Kita, Hideki, Matsuo, Hirotami, Takanaga, Hitomi, Kawakami, Junichi, Yamamoto, Koujirou, Iga, Tatsuji, Naito, Mikihiko, Tsuruo, Takashi, Asanuma, Atsushi, Yanagisawa, Keiji, Sawada, Yasufumi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Pharmacology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89116/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10223919/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.5.1091
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