P-Glycoprotein-Mediated Transport of Itraconazole across the Blood-Brain Barrier

The mechanism for the accumulation of itraconazole (ITZ) in its elimination from the brain was studied in rats and mice. The concentration of ITZ in liver tissue declined in parallel with the plasma ITZ concentration until 24 h after intravenous injection of the drug (half-life, 5 h); however, the I...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Miyama, Tetsuo, Takanaga, Hitomi, Matsuo, Hirotami, Yamano, Katsuhiro, Yamamoto, Koujirou, Iga, Tatsuji, Naito, Mikihiko, Tsuruo, Takashi, Ishizuka, Hitoshi, Kawahara, Yukinori, Sawada, Yasufumi
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1998
Fag:	Pharmacology
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105676/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9661014/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1738
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