P-Glycoprotein-Mediated Transport of Itraconazole across the Blood-Brain Barrier

The mechanism for the accumulation of itraconazole (ITZ) in its elimination from the brain was studied in rats and mice. The concentration of ITZ in liver tissue declined in parallel with the plasma ITZ concentration until 24 h after intravenous injection of the drug (half-life, 5 h); however, the I...

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Podrobná bibliografie

Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Miyama, Tetsuo, Takanaga, Hitomi, Matsuo, Hirotami, Yamano, Katsuhiro, Yamamoto, Koujirou, Iga, Tatsuji, Naito, Mikihiko, Tsuruo, Takashi, Ishizuka, Hitoshi, Kawahara, Yukinori, Sawada, Yasufumi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1998
Témata:	Pharmacology
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105676/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9661014/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1738
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