P-Glycoprotein-Mediated Transport of Itraconazole across the Blood-Brain Barrier

The mechanism for the accumulation of itraconazole (ITZ) in its elimination from the brain was studied in rats and mice. The concentration of ITZ in liver tissue declined in parallel with the plasma ITZ concentration until 24 h after intravenous injection of the drug (half-life, 5 h); however, the I...

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Argitaratua izan da:	Antimicrob Agents Chemother
Egile Nagusiak:	Miyama, Tetsuo, Takanaga, Hitomi, Matsuo, Hirotami, Yamano, Katsuhiro, Yamamoto, Koujirou, Iga, Tatsuji, Naito, Mikihiko, Tsuruo, Takashi, Ishizuka, Hitoshi, Kawahara, Yukinori, Sawada, Yasufumi
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Microbiology (ASM) 1998
Gaiak:	Pharmacology
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105676/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9661014/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1738
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