P-Glycoprotein-Mediated Transport of Itraconazole across the Blood-Brain Barrier

The mechanism for the accumulation of itraconazole (ITZ) in its elimination from the brain was studied in rats and mice. The concentration of ITZ in liver tissue declined in parallel with the plasma ITZ concentration until 24 h after intravenous injection of the drug (half-life, 5 h); however, the I...

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Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Miyama, Tetsuo, Takanaga, Hitomi, Matsuo, Hirotami, Yamano, Katsuhiro, Yamamoto, Koujirou, Iga, Tatsuji, Naito, Mikihiko, Tsuruo, Takashi, Ishizuka, Hitoshi, Kawahara, Yukinori, Sawada, Yasufumi
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1998
Matèries:	Pharmacology
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105676/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9661014/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1738
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