An Alternative Animal Model for Comparison of Treatments for Cryptococcal Meningitis

Weanling outbred rats were infected with Cryptococcus neoformans by direct percranial puncture and inoculation into the cranium. A lethal infection ensued. Treatment with LY295337, a depsipeptide with antifungal activity, was effective in prolonging survival and reducing fungal counts in brain tissu...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Najvar, Laura K., Bocanegra, Rosie, Graybill, John R.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1999
Sujets:	Experimental Therapeutics
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89093/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9925548/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.2.413
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