Metabolic Studies on BMS-200475, a New Antiviral Compound Active against Hepatitis B Virus

BMS-200475 was recently shown to have potent antiviral activity against hepatitis B virus (50% effective concentration = 3.7 nM; 50% cytotoxic concentration = 30 μM). In metabolic studies in both HepG2 and hepatitis B virus-transfected 2.2.15 human hepatoma cell lines, the metabolism was similar, th...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Yamanaka, Gregory, Wilson, Todd, Innaimo, Steven, Bisacchi, Gregory S., Egli, Peter, Rinehart, J. Kent, Zahler, Robert, Colonno, Richard J.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89048/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9869593/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.1.190
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