c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and Ubiquitination

The p53 protein is subject to Mdm2-mediated degradation by the ubiquitin-proteasome pathway. This degradation requires interaction between p53 and Mdm2 and the subsequent ubiquitination and nuclear export of p53. Exposure of cells to DNA damage results in the stabilization of the p53 protein in the...

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Sonraí Bibleagrafaíochta
Main Authors: Vogt Sionov, Ronit, Coen, Sabrina, Goldberg, Zehavit, Berger, Michael, Bercovich, Beatrice, Ben-Neriah, Yinon, Ciechanover, Aaron, Haupt, Ygal
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2001
Ábhair:
Cell Growth and Development
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC87306/
https://ncbi.nlm.nih.gov/pubmed/11486026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.17.5869-5878.2001
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