c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and Ubiquitination

The p53 protein is subject to Mdm2-mediated degradation by the ubiquitin-proteasome pathway. This degradation requires interaction between p53 and Mdm2 and the subsequent ubiquitination and nuclear export of p53. Exposure of cells to DNA damage results in the stabilization of the p53 protein in the...

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Detalhes bibliográficos
Main Authors: Vogt Sionov, Ronit, Coen, Sabrina, Goldberg, Zehavit, Berger, Michael, Bercovich, Beatrice, Ben-Neriah, Yinon, Ciechanover, Aaron, Haupt, Ygal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC87306/
https://ncbi.nlm.nih.gov/pubmed/11486026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.17.5869-5878.2001
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