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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.
In response to environmental stress, the p53 phosphoprotein is stabilized and activated to inhibit cell growth. p53 stability and activity are negatively regulated by the murine double minute (Mdm2) oncoprotein in an autoregulatory feedback loop. The inhibitory effect of Mdm2 on p53 has to be tightl...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
1999
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171266/ https://ncbi.nlm.nih.gov/pubmed/10202144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.7.1805 |
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