c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and Ubiquitination

The p53 protein is subject to Mdm2-mediated degradation by the ubiquitin-proteasome pathway. This degradation requires interaction between p53 and Mdm2 and the subsequent ubiquitination and nuclear export of p53. Exposure of cells to DNA damage results in the stabilization of the p53 protein in the...

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Détails bibliographiques
Auteurs principaux: Vogt Sionov, Ronit, Coen, Sabrina, Goldberg, Zehavit, Berger, Michael, Bercovich, Beatrice, Ben-Neriah, Yinon, Ciechanover, Aaron, Haupt, Ygal
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2001
Sujets:
Cell Growth and Development
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC87306/
https://ncbi.nlm.nih.gov/pubmed/11486026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.17.5869-5878.2001
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