Increased Susceptibility to Streptozotocin-Induced β-Cell Apoptosis and Delayed Autoimmune Diabetes in Alkylpurine- DNA-N-Glycosylase-Deficient Mice

Type 1 diabetes is thought to occur as a result of the loss of insulin-producing pancreatic β cells by an environmentally triggered autoimmune reaction. In rodent models of diabetes, streptozotocin (STZ), a genotoxic methylating agent that is targeted to the β cells, is used to trigger the initial c...

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Bibliographische Detailangaben
Hauptverfasser: Cardinal, John W., Margison, Geoffrey P., Mynett, Kurt J., Yates, Allen P., Cameron, Donald P., Elder, Rhoderick H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC87281/
https://ncbi.nlm.nih.gov/pubmed/11463841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.16.5605-5613.2001
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