Differential Regulation of Retinoblastoma Tumor Suppressor Protein by G(1) Cyclin-Dependent Kinase Complexes In Vivo

The retinoblastoma tumor suppressor protein (pRB) negatively regulates early-G(1) cell cycle progression, in part, by sequestering E2F transcription factors and repressing E2F-responsive genes. Although pRB is phosphorylated on up to 16 cyclin-dependent kinase (Cdk) sites by multiple G(1) cyclin-Cdk...

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Hauptverfasser: Ezhevsky, Sergei A., Ho, Alan, Becker-Hapak, Michelle, Davis, Penny K., Dowdy, Steven F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC87164/
https://ncbi.nlm.nih.gov/pubmed/11416152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.14.4773-4784.2001
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