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Distinct and nonoverlapping roles for pRB and cyclin D:cyclin-dependent kinases 4/6 activity in melanocyte survival
Deregulation of the p16(INK4a)–cyclin D:cyclin-dependent kinases (cdk) 4/6 –retinoblastoma (pRB) pathway is a common paradigm in the oncogenic transformation of human cells and suggests that this pathway functions linearly in malignant transformation. However, it is not understood why p16(INK4a) and...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC299840/ https://ncbi.nlm.nih.gov/pubmed/14630948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2431391100 |
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