Distinct and nonoverlapping roles for pRB and cyclin D:cyclin-dependent kinases 4/6 activity in melanocyte survival

Deregulation of the p16(INK4a)–cyclin D:cyclin-dependent kinases (cdk) 4/6 –retinoblastoma (pRB) pathway is a common paradigm in the oncogenic transformation of human cells and suggests that this pathway functions linearly in malignant transformation. However, it is not understood why p16(INK4a) and...

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Bibliographic Details
Main Authors: Yu, Benjamin D., Becker-Hapak, Michelle, Snyder, Eric L., Vooijs, Marc, Denicourt, Catherine, Dowdy, Steven F.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC299840/
https://ncbi.nlm.nih.gov/pubmed/14630948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2431391100
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