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Differential Regulation of Retinoblastoma Tumor Suppressor Protein by G(1) Cyclin-Dependent Kinase Complexes In Vivo
The retinoblastoma tumor suppressor protein (pRB) negatively regulates early-G(1) cell cycle progression, in part, by sequestering E2F transcription factors and repressing E2F-responsive genes. Although pRB is phosphorylated on up to 16 cyclin-dependent kinase (Cdk) sites by multiple G(1) cyclin-Cdk...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC87164/ https://ncbi.nlm.nih.gov/pubmed/11416152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.14.4773-4784.2001 |
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