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RAG Transposase Can Capture and Commit to Target DNA before or after Donor Cleavage

The discovery that the V(D)J recombinase functions as a transposase in vitro suggests that transposition by this system might be a potent source of genomic instability. To gain insight into the mechanisms that regulate transposition, we investigated a phenomenon termed target commitment that reflect...

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Bibliográfalaš dieđut
Publikašuvnnas:Mol Cell Biol
Váldodahkkit: Neiditch, Matthew B., Lee, Gregory S., Landree, Mark A., Roth, David B.
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Taylor & Francis 2001
Fáttát:
Liŋkkat:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87090/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11390658/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.13.4302-4310.2001
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