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DNA Strand Break-Sensing Molecule Poly(ADP-Ribose) Polymerase Cooperates with p53 in Telomere Function, Chromosome Stability, and Tumor Suppression

Genomic instability is often caused by mutations in genes that are involved in DNA repair and/or cell cycle checkpoints, and it plays an important role in tumorigenesis. Poly(ADP-ribose) polymerase (PARP) is a DNA strand break-sensing molecule that is involved in the response to DNA damage and the m...

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Detalhes bibliográficos
Main Authors: Tong, Wei-Min, Hande, M. Prakash, Lansdorp, Peter M., Wang, Zhao-Qi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC87066/
https://ncbi.nlm.nih.gov/pubmed/11359911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.12.4046-4054.2001
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