Retinoblastoma Tumor Suppressor Protein Signals through Inhibition of Cyclin-Dependent Kinase 2 Activity To Disrupt PCNA Function in S Phase

The retinoblastoma tumor suppressor protein (RB) is a negative regulator of the cell cycle that inhibits both G(1) and S-phase progression. While RB-mediated G(1) inhibition has been extensively studied, the mechanism utilized for S-phase inhibition is unknown. To delineate the mechanism through whi...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Sever-Chroneos, Zvjezdana, Angus, Steven P., Fribourg, Anne F., Wan, Huajing, Todorov, Ivan, Knudsen, Karen E., Knudsen, Erik S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2001
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87065/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11359910/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.12.4032-4045.2001
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