Retinoblastoma Tumor Suppressor Protein Signals through Inhibition of Cyclin-Dependent Kinase 2 Activity To Disrupt PCNA Function in S Phase

The retinoblastoma tumor suppressor protein (RB) is a negative regulator of the cell cycle that inhibits both G(1) and S-phase progression. While RB-mediated G(1) inhibition has been extensively studied, the mechanism utilized for S-phase inhibition is unknown. To delineate the mechanism through whi...

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Detalhes bibliográficos
Main Authors: Sever-Chroneos, Zvjezdana, Angus, Steven P., Fribourg, Anne F., Wan, Huajing, Todorov, Ivan, Knudsen, Karen E., Knudsen, Erik S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC87065/
https://ncbi.nlm.nih.gov/pubmed/11359910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.12.4032-4045.2001
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