HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator composed of HIF-1α and HIF-1β subunits. Several dozen HIF-1 targets are known, including the gene encoding vascular endothelial growth factor (VEGF). Under hypoxic conditions, HIF-1α expression increases as a result of decreased ubiqu...

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Détails bibliographiques
Auteurs principaux: Laughner, Erik, Taghavi, Panthea, Chiles, Kelly, Mahon, Patrick C., Semenza, Gregg L.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2001
Sujets:
Cell Growth and Development
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC87062/
https://ncbi.nlm.nih.gov/pubmed/11359907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.12.3995-4004.2001
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