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Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α

Hypoxia-inducible factors (HIFs) are transcription factors that mediate adaptive responses to reduced oxygen availability. HIF-α subunits are stabilized under conditions of acute hypoxia. However, prolonged hypoxia leads to decay of HIF-1α but not HIF-2α protein levels by unknown mechanisms. Here, w...

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Autori principali: Luo, Weibo, Zhong, Jun, Chang, Ryan, Hu, Hongxia, Pandey, Akhilesh, Semenza, Gregg L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823506/
https://ncbi.nlm.nih.gov/pubmed/19940151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.068577
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