Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration

Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator in response to hypoxia and its transcriptional activity is crucial for cancer cell mobility. Here we present evidence for a novel epigenetic mechanism that regulates HIF-1 transcriptional activity and HIF-1-dependent migration...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Bao, Lei, Chen, Yan, Lai, Hsien-Tsung, Wu, Shwu-Yuan, Wang, Jennifer E, Hatanpaa, Kimmo J, Raisanen, Jack M, Fontenot, Miles, Lega, Bradley, Chiang, Cheng-Ming, Semenza, Gregg L, Wang, Yingfei, Luo, Weibo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061882/
https://ncbi.nlm.nih.gov/pubmed/29860315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky449
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