The Oncogene HER2/neu (ERBB2) Requires the Hypoxia-inducible Factor HIF-1 for Mammary Tumor Growth and Anoikis Resistance

ERBB2, a receptor tyrosine kinase amplified in breast cancer, is a well established regulator of tumor growth in vivo and anoikis resistance leading to disruption of architecture in three-dimensional mammary epithelial acinar structures in vitro. ERBB2 promotes anoikis resistance by maintaining sign...

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Bibliografische gegevens
Hoofdauteurs: Whelan, Kelly A., Schwab, Luciana P., Karakashev, Sergey V., Franchetti, Lisa, Johannes, Gregg J., Seagroves, Tiffany N., Reginato, Mauricio J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2013
Onderwerpen:
Molecular Bases of Disease
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668743/
https://ncbi.nlm.nih.gov/pubmed/23585570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.426999
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