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Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

Fatty acid synthase (FAS) activity is a potential therapeutic target to treat cancer and obesity. Here, we have identified a molecular link between FAS and HER2 (erbB-2) oncogene, a marker for poor prognosis that is overexpressed in 30% of breast and ovarian cancers. Pharmacological FAS inhibitors c...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Menendez, Javier A., Vellon, Luciano, Mehmi, Inderjit, Oza, Bharvi P., Ropero, Santiago, Colomer, Ramon, Lupu, Ruth
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2004
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC490000/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15235125/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0403390101
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