RAG-1 Mutations Associated with B-Cell-Negative SCID Dissociate the Nicking and Transesterification Steps of V(D)J Recombination

Some patients with B-cell-negative severe combined immune deficiency (SCID) carry mutations in RAG-1 or RAG-2 that impair V(D)J recombination. Two recessive RAG-1 mutations responsible for B-cell-negative SCID, R621H and E719K, impair V(D)J recombination without affecting formation of single-site re...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Li, Wenhui, Chang, Fu-Chung, Desiderio, Stephen
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 2001
Fag:	DNA Dynamics and Chromosome Structure
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87056/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11359901/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.12.3935-3946.2001
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