Embryonic but Not Postnatal Reexpression of Hepatocyte Nuclear Factor 1α (HNF1α) Can Reactivate the Silent Phenylalanine Hydroxylase Gene in HNF1α-Deficient Hepatocytes

Eitemau Tebyg

• Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1).
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• Hepatocyte Nuclear Factor 1α Controls the Expression of Terminal Complement Genes
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• Hepatocyte nuclear factor 1alpha gene inactivation impairs chromatin remodeling and demethylation of the phenylalanine hydroxylase gene.
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• HNF1α controls renal glucose reabsorption in mouse and man
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• Mitochondrial Dysfunction Contributes to Impaired Insulin Secretion in INS-1 Cells with Dominant-negative Mutations of HNF-1α and in HNF-1α-deficient Islets
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  Cyhoeddwyd: (2009)