Embryonic but Not Postnatal Reexpression of Hepatocyte Nuclear Factor 1α (HNF1α) Can Reactivate the Silent Phenylalanine Hydroxylase Gene in HNF1α-Deficient Hepatocytes

The failure to transcribe the phenylalanine hydroxylase (PAH) gene in the liver of hepatocyte nuclear factor 1α (HNF1α)-deficient mice correlated with DNA hypermethylation and the presence of an inactive chromatin structure (M. Pontoglio, D. M. Faust, A. Doyen, M. Yaniv, and M. C. Weiss, Mol. Cell....

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Bibliographic Details
Main Authors: Viollet, Benoît, Yaniv, Moshe, Pontoglio, Marco
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC86995/
https://ncbi.nlm.nih.gov/pubmed/11340160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.11.3662-3670.2001
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