Immune System Dysfunction and Autoimmune Disease in Mice Lacking Emk (Par-1) Protein Kinase

Emk is a serine/threonine protein kinase implicated in regulating polarity, cell cycle progression, and microtubule dynamics. To delineate the role of Emk in development and adult tissues, mice lacking Emk were generated by targeted gene disruption. Emk(−/−) mice displayed growth retardation and imm...

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Autores principales: Hurov, Jonathan B., Stappenbeck, Thaddeus S., Zmasek, Christian M., White, Lynn S., Ranganath, Sheila H., Russell, John H., Chan, Andrew C., Murphy, Kenneth M., Piwnica-Worms, Helen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC86958/
https://ncbi.nlm.nih.gov/pubmed/11287624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.9.3206-3219.2001
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