Disruption of the Cockayne Syndrome B Gene Impairs Spontaneous Tumorigenesis in Cancer-Predisposed Ink4a/ARF Knockout Mice

Cells isolated from individuals with Cockayne syndrome (CS) have a defect in transcription-coupled DNA repair, which rapidly corrects certain DNA lesions located on the transcribed strand of active genes. Despite this DNA repair defect, individuals with CS group A (CSA) or group B (CSB) do not exhib...

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Autors principals: Lu, Yi, Lian, Hanzhou, Sharma, Prerna, Schreiber-Agus, Nicole, Russell, Robert G., Chin, Lynda, van der Horst, Gijsbertus T. J., Bregman, David B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
DNA Dynamics and Chromosome Structure
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC86742/
https://ncbi.nlm.nih.gov/pubmed/11238917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.5.1810-1818.2001
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