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Checkpoint Adaptation Precedes Spontaneous and Damage-Induced Genomic Instability in Yeast

Despite the fact that eukaryotic cells enlist checkpoints to block cell cycle progression when their DNA is damaged, cells still undergo frequent genetic rearrangements, both spontaneously and in response to genotoxic agents. We and others have previously characterized a phenomenon (adaptation) in w...

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Autors principals: Galgoczy, David J., Toczyski, David P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC86717/
https://ncbi.nlm.nih.gov/pubmed/11238908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.5.1710-1718.2001
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