Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability

In cells lacking telomerase, telomeres gradually shorten during each cell division to reach a critically short length, permanently activate the DNA damage checkpoint, and trigger replicative senescence. The increase in genome instability that occurs as a consequence may contribute to the early steps...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Genes Dev
Egile Nagusiak: Coutelier, Héloïse, Xu, Zhou, Morisse, Mony Chenda, Lhuillier-Akakpo, Maoussi, Pelet, Serge, Charvin, Gilles, Dubrana, Karine, Teixeira, Maria Teresa
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2018
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295172/
https://ncbi.nlm.nih.gov/pubmed/30463903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.318485.118
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