Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53

The cellular function of p53 is complex. It is well known that p53 plays a key role in cellular response to DNA damage. Moreover, p53 was implicated in cellular senescence, and it was demonstrated that p53 undergoes modification in senescent cells. However, it is not known how these modifications af...

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Autors principals: Seluanov, Andrei, Gorbunova, Vera, Falcovitz, Ayellet, Sigal, Alex, Milyavsky, Michael, Zurer, Irit, Shohat, Galit, Goldfinger, Naomi, Rotter, Varda
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC86701/
https://ncbi.nlm.nih.gov/pubmed/11238892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.5.1552-1564.2001
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