Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53

The cellular function of p53 is complex. It is well known that p53 plays a key role in cellular response to DNA damage. Moreover, p53 was implicated in cellular senescence, and it was demonstrated that p53 undergoes modification in senescent cells. However, it is not known how these modifications af...

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Detalhes bibliográficos
Main Authors: Seluanov, Andrei, Gorbunova, Vera, Falcovitz, Ayellet, Sigal, Alex, Milyavsky, Michael, Zurer, Irit, Shohat, Galit, Goldfinger, Naomi, Rotter, Varda
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86701/
https://ncbi.nlm.nih.gov/pubmed/11238892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.5.1552-1564.2001
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