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Changes in the level and distribution of Ku proteins during cellular senescence
Aging is associated with accumulation of genomic rearrangements consistent with aberrant repair of DNA breaks. We have shown previously that DNA repair by nonhomologous end joining (NHEJ) becomes less efficient and more error-prone in senescent cells. Here we show that the levels of Ku70 and Ku80 dr...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699370/ https://ncbi.nlm.nih.gov/pubmed/17686666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2007.06.010 |
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