Grb2 and Shc Adapter Proteins Play Distinct Roles in Neu (ErbB-2)-Induced Mammary Tumorigenesis: Implications for Human Breast Cancer

Amplification of the Neu (ErbB-2 or HER-2) receptor tyrosine kinase occurs in 20 to 30% of human mammary carcinomas, correlating with a poor clinical prognosis. We have previously demonstrated that four (Y1144 Y1201, Y1227 and Y1253) of the five known Neu autophosphorylation sites can independently...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Dankort, David, Maslikowski, Bart, Warner, Neil, Kanno, Nubufumi, Kim, Harold, Wang, Zhixiang, Moran, Michael F., Oshima, Robert G., Cardiff, Robert D., Muller, William J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2001
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86700/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238891/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.5.1540-1551.2001
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