Grb2 and Shc Adapter Proteins Play Distinct Roles in Neu (ErbB-2)-Induced Mammary Tumorigenesis: Implications for Human Breast Cancer

Amplification of the Neu (ErbB-2 or HER-2) receptor tyrosine kinase occurs in 20 to 30% of human mammary carcinomas, correlating with a poor clinical prognosis. We have previously demonstrated that four (Y1144 Y1201, Y1227 and Y1253) of the five known Neu autophosphorylation sites can independently...

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Detalhes bibliográficos
Main Authors: Dankort, David, Maslikowski, Bart, Warner, Neil, Kanno, Nubufumi, Kim, Harold, Wang, Zhixiang, Moran, Michael F., Oshima, Robert G., Cardiff, Robert D., Muller, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2001
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86700/
https://ncbi.nlm.nih.gov/pubmed/11238891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.5.1540-1551.2001
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