Mutational and Structural Analyses of the Ribonucleotide Reductase Inhibitor Sml1 Define Its Rnr1 Interaction Domain Whose Inactivation Allows Suppression of mec1 and rad53 Lethality

In budding yeast, MEC1 and RAD53 are essential for cell growth. Previously we reported that mec1 or rad53 lethality is suppressed by removal of Sml1, a protein that binds to the large subunit of ribonucleotide reductase (Rnr1) and inhibits RNR activity. To understand further the relationship between...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Zhao, Xiaolan, Georgieva, Bilyana, Chabes, Andrei, Domkin, Vladimir, Ippel, Johannes H., Schleucher, Jürgen, Wijmenga, Sybren, Thelander, Lars, Rothstein, Rodney
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 2000
Fag:	Cell Growth and Development
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86560/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11074005/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.23.9076-9083.2000
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