Mutational and Structural Analyses of the Ribonucleotide Reductase Inhibitor Sml1 Define Its Rnr1 Interaction Domain Whose Inactivation Allows Suppression of mec1 and rad53 Lethality

In budding yeast, MEC1 and RAD53 are essential for cell growth. Previously we reported that mec1 or rad53 lethality is suppressed by removal of Sml1, a protein that binds to the large subunit of ribonucleotide reductase (Rnr1) and inhibits RNR activity. To understand further the relationship between...

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Dades bibliogràfiques

Publicat a:	Mol Cell Biol
Autors principals:	Zhao, Xiaolan, Georgieva, Bilyana, Chabes, Andrei, Domkin, Vladimir, Ippel, Johannes H., Schleucher, Jürgen, Wijmenga, Sybren, Thelander, Lars, Rothstein, Rodney
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 2000
Matèries:	Cell Growth and Development
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86560/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11074005/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.23.9076-9083.2000
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