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Mutational and Structural Analyses of the Ribonucleotide Reductase Inhibitor Sml1 Define Its Rnr1 Interaction Domain Whose Inactivation Allows Suppression of mec1 and rad53 Lethality

In budding yeast, MEC1 and RAD53 are essential for cell growth. Previously we reported that mec1 or rad53 lethality is suppressed by removal of Sml1, a protein that binds to the large subunit of ribonucleotide reductase (Rnr1) and inhibits RNR activity. To understand further the relationship between...

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書誌詳細
主要な著者: Zhao, Xiaolan, Georgieva, Bilyana, Chabes, Andrei, Domkin, Vladimir, Ippel, Johannes H., Schleucher, Jürgen, Wijmenga, Sybren, Thelander, Lars, Rothstein, Rodney
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2000
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC86560/
https://ncbi.nlm.nih.gov/pubmed/11074005
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