Coupled Homologous and Nonhomologous Repair of a Double-Strand Break Preserves Genomic Integrity in Mammalian Cells

DNA double-strand breaks (DSBs) may be caused by normal metabolic processes or exogenous DNA damaging agents and can promote chromosomal rearrangements, including translocations, deletions, or chromosome loss. In mammalian cells, both homologous recombination and nonhomologous end joining (NHEJ) are...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Richardson, Christine, Jasin, Maria
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	DNA Dynamics and Chromosome Structure
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86559/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11074004/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.23.9068-9075.2000
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