Coupled Homologous and Nonhomologous Repair of a Double-Strand Break Preserves Genomic Integrity in Mammalian Cells

DNA double-strand breaks (DSBs) may be caused by normal metabolic processes or exogenous DNA damaging agents and can promote chromosomal rearrangements, including translocations, deletions, or chromosome loss. In mammalian cells, both homologous recombination and nonhomologous end joining (NHEJ) are...

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書誌詳細

出版年:	Mol Cell Biol
主要な著者:	Richardson, Christine, Jasin, Maria
フォーマット:	Artigo
言語:	Inglês
出版事項:	Taylor & Francis 2000
主題:	DNA Dynamics and Chromosome Structure
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86559/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11074004/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.23.9068-9075.2000
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